Specialized centres for cancer genomics, rare diseases, infectious diseases, and population genomics.
Centre of Excellence Programs
1. Cancer Genomics Centre of Excellence
Mission: Advance precision oncology through comprehensive molecular profiling and biomarker discovery.
Key Programs:
- Liquid biopsy development
- Tumor heterogeneity studies
- Immunotherapy biomarkers
- Hereditary cancer research
Infrastructure:
- Dedicated oncology laboratory
- Single-cell sequencing platform
- Spatial transcriptomics
- Patient-derived organoid facility
2. Rare Disease Centre of Excellence
Mission: End the diagnostic odyssey for patients with rare genetic disorders.
Key Programs:
- Whole genome sequencing for undiagnosed patients
- Functional validation of novel variants
- International rare disease consortia participation
- Patient advocacy and support
Infrastructure:
- Exome sequencing capability
- CRISPR/Cas9 gene editing facility
- Patient-derived cell lines
- Animal models
3. Infectious Disease Genomics Centre
Mission: Combat antimicrobial resistance and emerging infectious threats through genomic surveillance.
Key Programs:
- Whole genome sequencing of pathogens
- Antimicrobial resistance profiling
- Outbreak investigation
- Vaccine development support
Infrastructure:
- BSL-2 and BSL-3 laboratories
- Microbial sequencing platforms
- Bioinformatics for pathogen genomics
- Epidemiological modeling
4. Population Genomics Initiative
Mission: Build the largest genomic database of the Indian population to enable precision medicine.
Goals:
- Sequence 2 million genomes by 2030
- Identify population-specific variants
- Discover disease associations
- Support clinical interpretation
Collaborations:
- GenomeAsia 100K Project
- Indian Genome Variation Consortium
- All of Us Research Program (observer)
- International genomic consortia
Data Sharing:
- Public genomic databases
- Controlled-access research datasets
- Clinical variant databases
- Population frequency resources
